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They are often associated with other involuntary actions, including muscular spasms in multiple areas of the body, a general euphoric sensation and, frequently, body movements and vocalizations. Human orgasms usually result from physical sexual stimulation of the penis in males typically accompanying ejaculation , and the clitoris in females. The health effects surrounding the human orgasm are diverse. There are many physiological responses during sexual activity, including a relaxed state created by prolactin, as well as changes in the central nervous system such as a temporary decrease in the metabolic activity of large parts of the cerebral cortex while there is no change or increased metabolic activity in the limbic i. Orgasm in non-human animals has been studied significantly less than orgasm in humans, but research on the subject is ongoing.